From time to time you will need to clean out the Prefetch directory in Vista and XP. Here is how you do it in Vista. You first would need to boot into safe mode in Vista then you will log into Vista and go to:
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Having been using XP and Vista for the past few years, I’ve found that deleting all of the files in prefetch directory and letting them rebuild actually speeds up the system. I got a feeling it has something to do with file corruptions. After you go into the Prefetch directory and delete all the files. You would then go into your Readyboost Directory if you are using Readyboost then there will be a Readyboost directory inside the Prefetch directory. Deleting all the files in the Readyboost directory also will greatly improve performance of your system. Don’t delete the Prefetch Directory or the Readyboost Directory, Vista won’t let you delete the Prefetch but will with Readyboost. Deleting the Readyboost directory will prevent Vista from using Readyboost and then you would have to restart the process of using Readyboost.
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If you can come up with more ways to speed up Vista then by all means let me know!!